FBXO44 promotes DNA replication-coupled repetitive element silencing in cancer cells
نویسندگان
چکیده
منابع مشابه
Silencing repetitive DNA
Some RNAs in mammalian cells can help to silence the DNA they are transcribed from.
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It is well established that DNA hypermethylation of tumor suppressor and tumor-related genes can occur in cancer cells and that each cancer subtype has specific gene sets that are commonly susceptible to methylation and silencing. Glutathione S-transferase (GSTP1) is one example of a gene that is hypermethylated and inactivated in the majority of prostate cancers. We previously reported that hy...
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ژورنال
عنوان ژورنال: Cell
سال: 2021
ISSN: 0092-8674
DOI: 10.1016/j.cell.2020.11.042